|
|
| Medicine Information |
|
|
|
|
Aleve, Vioxx, Celebrex, and Bextra: What You Need To Know About Arthritis Pain Medications
Recent controversy about the safety of pain medications for arthritis has left patients and health care professionals alike confused about which medications are safe to use. In fact, a recent survey by the Boston-based Rippe Lifestyle Institute indicated that many people with arthritis are suffering unnecessarily because they have stopped or reduced their use of pain relievers due to confusion about which drugs are considered safe. The survey also showed that now, more than ever, those with arthritis need to understand the benefits and possible side effects associated with all arthritis pain medications. In order to do so, people with arthritis, their caregivers and families must be familiar with recent news about the two types of drugs most commonly used to treat arthritis pain non-selective, non-steroidal anti-inflammatory drugs (NSAIDs), and another group of NSAIDs known as cyclooxygenase-2 (COX-2) specific inhibitors. COX-2 specific inhibitors vs. Other NSAIDs COX-2 specific inhibitors are the newest members of the NSAID class of medications. Available by prescription only, they became widely used in recent years to reduce joint pain and swelling. COX-2 specific inhibitors work by selectively blocking, or inhibiting, one of the two enzymes associated with inflammation. Some experts think that this selective inhibition may be one reason for some of the negative side effects currently associated with COX-2 specific inhibitors. Non-selective NSAIDs were developed earlier than COX-2 specific inhibitors and have been widely used to relieve arthritis pain and inflammation for many years. Unlike COX-2 specific inhibitors, non-selective NSAIDs inhibit both major enzymes involved in the inflammatory process, COX-1 and COX-2. The non-selective NSAID category includes a number of different medications that are available in both prescription and over-the-counter (OTC) products. Timeline of Events To understand the current state of affairs, it is important to understand the sequence of events. The controversy started when a study published in the October 21, 2004, issue of the New England Journal of Medicine cited the COX-2 specific inhibitor, Vioxx as potentially causing "major adverse events," including heart attack and stroke, among patients taking the drug. As a result, Merck (the drug's manufacturer) voluntarily withdrew Vioxx from the market. However, in the months following, the safety of the other available COX-2 specific inhibitors such as Celebrex and Bextra, as well as other arthritis pain medications in the non-steroidal anti-inflammatory (NSAID) class, were also called into question. Consequently, in February 2005, the US Food and Drug Administration (FDA) convened a special Advisory Committee, made up of members of the Arthritis and Drug Safety Advisory Committees, to review the cardiovascular safety of these arthritis pain medications. FDA Directive: Stronger Warning Labels for Some Pain Medications On April 7, 2005, taking into account the recommendations of the Advisory Committee, the FDA issued the following directives: ? Bextra, a COX-2 specific inhibitor manufactured by Pfizer, was withdrawn from the market. ? All prescription NSAIDs must revise their labeling to include a "black box" warning that highlights the potential increased risk for cardiovascular (CV) events as well as the potentially life threatening gastrointestinal (GI) bleeding associated with these drugs. Celebrex, the only COX-2 specific inhibitor remaining on the US market, was included in this directive. ? All OTC NSAIDs (except aspirin) will be required to revise their labeling to include more specific information about the potential for GI and CV side effects, a stronger reminder to follow label instructions, as well as a warning about potential skin reactions. To further evaluate the potential for increased CV risk, the FDA also announced that all NSAIDs must conduct and submit to the FDA a comprehensive review and analysis of pertinent safety data from clinical trials. ? Aleve (naproxen sodium) is supported by clinical studies conducted to gain approval of naproxen as a prescription product and as OTC that do not provide any evidence of increased risk of cardiovascular events. Treatment Options: What Should Arthritis Patients Know? For some people who suffer from pain associated with arthritis, their symptoms can be managed with exercise, heat/cold therapy, joint protection, assistive devices, weight control, or in some severe cases, surgery. For others, medications are needed to help manage the symptoms associated with arthritis. When taken as directed OTC medications such as Aleve provide a safe and effective way to treat mild to moderate pain of minor arthritis. If patients have questions, they should consult their health care professional about which treatment option is most appropriate. Why It's Important to Treat Arthritis Arthritis affects approximately 66 million Americans and is the nation's leading cause of disability. There are over 100 different types of arthritis, and they all have different symptoms that vary in severity from person to person. The most common form of arthritis, osteoarthritis, is characterized by the breakdown of cartilage that causes the bones to rub together, resulting in pain, loss of movements and stiffness. Arthritis is usually a chronic condition. For more information on Aleve and naproxen, visit the Aleve website at www.aleve.com. For more information on arthritis pain relief, visit www.arthritis.org Please visit http://www.aleve.com for more information.
Google News |
|
|
|
Alternative Medicine Powerful Arthritis Pain Relief For All Of Us When you ask what arthritis is, professinals will tell you it's inflammation of one or more joints. But you know it better as pain, swelling, stiffness, deformity, and/or a diminished range of motion of those joints! It's estimated that over 50 million Americans suffer from osteoarthritis, rheumatoid arthritis and other related conditions. Prescription Drug Benefit Cost Understated by $324 Billion! When the legislation was passed for Bush's prescription drug benefit in 2003, costs were said to be approximately $400 billion over the next decade. In great contradiction with this estimate, the centers for Medicaid and Medicare have admitted that costs will actually be around $724 billion. How to Remove the Psychological Addiction to Smoking - and Start to ENJOY Giving Up Smoking! Consider this: Ooohhh my aching knee!!! Insider Secrets on How You Can Get Relief Quickly and Easily! When your knee hurts, getting relief is all that's on your mind. Getting the right relief, though, depends on knowing what's wrong. The correct diagnosis will lead to the correct treatment. Talking Money with Your Doctor: Drugs and Tests for Less Would you buy groceries without knowing their prices? I suspect not. You probably compare the costs of different boxes of cereal in order to get the best deal. But when it comes to medical care, do you even ask for the prices involved? Zyprexa Lawsuits Zyprexa is an antipsychotic medication that works by changing the actions of chemicals in the brain. Zyprexa is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder. Zyprexa may also be used for other purposes. Celebrex Side Effects Lawsuit Lawyer The Food and Drug administration urges people to stop taking Celebrex, but even so the drug has remained on the market. Recent studies have found that Celebrex causes heart attacks and strokes at higher doses. These same problems have lead rival pharmaceutical company Merck & Co to remove its painkiller Vioxx from the market. However, Pfizer, the maker of Celebrex, is leaving its dangerous drug on the market. 3 Facts Everyone Should Know About Stem Cells Cord Blood A Fresh Start Plan for People With Neck Pain! "If you have to deal with chronic neck pain, it can be a real struggle. I know? because I've had to do it myself," states Dr. Nathan Wei, a board-certified rheumatologist and Clinical Director of The Arthritis and Osteoporosis Center of Maryland. Cold-Eeze Side Effects Lawyer: Zinc Destroys Sense of Smell! Cold-Eeze is a homeopathic solution to the common cold. It is a zinc-based solution that can be taken as a tablet or a nasal spray. Limited studies have found that the nasal spray reduces the duration of the common cold to less than three days, down from an average nine days. These amazing results have lead thousands of Americans to try this new medication, with terrible results. Vioxx Personal Injury Lawsuits Personal injury attorneys representing clients who have allegedly been harmed by the prescription drug Vioxx are congratulating themselves over a historic judgment rendered recently. On August 19, 2005, a judge awarded the family of Bob Ernst $253.4 million due to his death from the drug. Vioxx, which had been prescribed most often for arthritis pain, was withdrawn globally by its maker, Merck, after research trials showed it increased patients' chances of a heart attack. Although Merck pulled the drug off the market in September 2004, legal action against this leading pharmaceutical giant will continue and expand. Let's take a look at why Vioxx has become a litigation lightning rod. Risperdal Side Effects: Neuroleptic Malignant Syndrome NMS Risperdal is an atypical anti-psychotic drug that balances the levels of dopamine and serotonin in the brain. It helps to stabilize patients with mental illness including the manic stages of bipolar disorder and schizophrenia. However Risperdal has been prescribed not just for people with mental illness, but also for children and the elderly who have behavioral and conduct disorders and for autism. Studies have only approved Risperdal for use with adults, not children. Children on Risperdal could retain lasting side effects. OxyContin Addiction: Doctors & Drug Lords OxyContin is a narcotic drug, an opiate, that has been approved by the FDA to legally treat chronic pain. Chronic pain is documented medical condition, a progressive disease of the nervous system and spine that causes constant a patient to experience constant, excruciating pain. Chronic pain is caused by the failure of the body's internal pain control systems and is accompanied by changes of the chemical and anatomical makeup of the spinal cord. Left untreated, the condition will spread to unaffected areas. A patient suffering from chronic pain does not produce enough natural opiates, so a pharmaceutical opiate like OxyContin is an effective treatment for the disease. Propulsid Litigation Lawyer Says: Unnecessary Drug Killed 80 People Propulsid was a popular nighttime heartburn drug before it was pulled in the market in March of 2000. It was linked to dozens of fatal heart rhythm abnormalities. A Food and Drug Administration (FDA) document associated the drug with 341 reports of heart rhythm abnormalities and 80 reported deaths. The FDA also acknowledges that only a small fraction of problems with a drug are ever reported. Top Ten Reasons Why We Hate IBS! Irritable bowel syndrome can be a nightmare?constant diarrhea and terrible stomach pains, or unbelievable constipation and never-ending gas. While it's good to stay positive and keep looking for help, sometimes it's even better to just have a good old moan! Relafen: A New Drug with an Old Danger Individuals who regularly take Relafen (nabumetone) or other anti-inflammatory medications, either for arthritis, joint pain, or other indications, should be aware of severe adverse health implications that can potentially result from prolonged use. Relafen is usually prescribed for osteoarthritis or rheumatoid arthritis to reduce pain, inflammation, and stiffness, but can also be prescribed for other purposes. Relafen works by reducing the level of hormones in the body that can cause pain and inflammation. In addition to the warnings provided with the packaging of the medication and those related by a physician, there are other important concerns that users of Relafen should know about. A Look at the Different Acid Reflux Symptoms Acid reflux symptoms vary in degrees of discomfort, from person to person, and within different age groups. The most common and persistent symptom is a burning sensation centered in the middle of the chest and/or throat, brought on by stomach acid that churns up onto the lining of the esophagus. This is due to the relaxing of the esophageal sphincter (valve), which remains open when it should be closed. Acid reflux also leads to one of the most unpleasant symptoms known as regurgitation of acid into the mouth, often due to overeating, or bending down after a meal. Phenylpropanolamine (PPH) Lawyer: Decongestant Causes Stroke Phenylpropanolamine, or PPH, used to be an active ingredient in many over the counter nasal decongestants and weight control drug products. The FDA pulled phenylpropanolamine off the market in May of 2000 when a Yale University School of Medicine study found that patients using PPH were at a higher risk of hemorrhagic stroke, or bleeding of the brain. By then it had been in popular use for many years, but because strokes are such serious and unpredictable afflictions and safer alternative drugs readily available, the FDA alerted customers to the danger and issued a recall on phenylpropanolamine. Prevent Foot Problems When Walking Americans are on the go. According to a NSGA Survey, 71 million American adults are exercise walkers, making walking the top sport in the United States. Taking steps daily to improve health will help with America's obesity epidemic. Sixty five percent of Americans are overweight, which is linked to diabetes, heart disease, arthritis and some types of cancer. Walking an extra 2000 steps a day is equivalent to walking a distance of 1 mile and to burning 100 calories. Burning an extra 100 calories a day is equivalent to losing about 10 pounds in a year. Overview of FDA Recalled Drug - BEXTRA Bextra, also known as valdecoxib, is a prescription medicine known as a COX-2 Inhibitor. Like Vioxx and Celebrex, it supposedly lessen the pain of inflammation and fever without causing stomach irritation common to aspirin and other NSAIDs (Non-Steroidal Anti-Inflammatory Drugs). Pharmaceutical corporation Pfizer released Bextra in 2001, and prescription sales soon rose to 3.2 billion dollars.
|
|
|
|
© 2009 www.elearn-university.org |
